Naftidrofuril

Naftidrofuril
Nama sistematis (IUPAC)
	(RS)-2-(dietilamino)etil 3-(1-naftil)-2-(tetrahidrofuran-2-ilmetil)propanoat
Data klinis
Nama dagang	Praxilene
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	POM (UK)
Rute	Oral
Data farmakokinetik
Metabolisme	Hati
Waktu paruh	1 - 3,5 jam
Pengenal
Nomor CAS	31329-57-4
Kode ATC	C04AX21
PubChem	CID 4417
ChemSpider	4264
UNII	42H8PQ0NMJ
ChEMBL	CHEMBL1620794
Data kimia
Rumus	C24H33NO3
SMILES	eMolecules & PubChem
	InChI InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 ; Key:KBAFPSLPKGSANY-UHFFFAOYSA-N ;

Naftidrofuril (INN), juga dikenal sebagai nafronil atau sebagai garam oksalatnya yakni naftidrofuril oksalat atau nafronil oksalat, adalah vasodilator yang digunakan dalam pengelolaan gangguan vaskular perifer dan serebral. Obat ini juga diklaim dapat meningkatkan kapasitas oksidatif seluler. Obat ini bertindak sebagai antagonis selektif reseptor 5-HT₂ (dengan aksi sebagai agonis terbalik dari reseptor 5-HT_2A yang dicirikan secara khusus).^[1]^[2]^[3] Naftidrofuril juga dilisensikan untuk pengobatan klaudikasio intermiten karena penyakit arteri perifer.

Secara historis, obat ini telah digunakan untuk mengobati gangguan pendengaran idiopatik mendadak dan tinitus akut.^[4]

Naftidrofuril mungkin efektif untuk meredakan nyeri kram otot.^[5]

Efek samping

Naftidrofuril telah dikaitkan dengan mual, mulas, dan ruam. Hepatitis dan gagal hati telah dilaporkan, namun jarang.^[6]

Referensi

^ Lanzer P, Topol EJ (20 December 2013). Pan Vascular Medicine: Integrated Clinical Management. Springer. hlm. 1394–. ISBN 978-3-642-56225-9.
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 147–. ISBN 978-94-011-4439-1.
^ Aly SA, Hossain M, Bhuiyan MA, Nakamura T, Nagatomo T (August 2009). "Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate". Journal of Pharmacological Sciences. 110 (4): 445–50. doi:10.1254/jphs.09124FP. PMID 19672037.
^ "DER ARZNEIMITTELBRIEF: Infusionstherapie beim idiopathischen Hörsturz? Dextran Dextran Hörsturz Hydroxyethylstärke Pentoxifyllin Pentoxifyllin Procain Taprosten". www.der-arzneimittelbrief.de.
^ Katzberg HD, Khan AH, So YT (February 2010). "Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology". Neurology. 74 (8): 691–6. doi:10.1212/WNL.0b013e3181d0ccca. PMID 20177124.
^ Brayfield A, ed. (14 January 2014). "Naftidrofuryl Oxalate". Martindale: The Complete Drug Reference. Pharmaceutical Press. Diakses tanggal 6 August 2014.

[LanzerTopol2013-1] Lanzer P, Topol EJ (20 December 2013). Pan Vascular Medicine: Integrated Clinical Management. Springer. hlm. 1394–. ISBN 978-3-642-56225-9.

[MortonHall2012-2] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 147–. ISBN 978-94-011-4439-1.

[AlyHossain2009-3] Aly SA, Hossain M, Bhuiyan MA, Nakamura T, Nagatomo T (August 2009). "Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate". Journal of Pharmacological Sciences. 110 (4): 445–50. doi:10.1254/jphs.09124FP. PMID 19672037.

[4] "DER ARZNEIMITTELBRIEF: Infusionstherapie beim idiopathischen Hörsturz? Dextran Dextran Hörsturz Hydroxyethylstärke Pentoxifyllin Pentoxifyllin Procain Taprosten". www.der-arzneimittelbrief.de.

[Katzberg-5] Katzberg HD, Khan AH, So YT (February 2010). "Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology". Neurology. 74 (8): 691–6. doi:10.1212/WNL.0b013e3181d0ccca. PMID 20177124.

[MD-6] Brayfield A, ed. (14 January 2014). "Naftidrofuryl Oxalate". Martindale: The Complete Drug Reference. Pharmaceutical Press. Diakses tanggal 6 August 2014.

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